Burn Scar Management
- Key Cell Functions are Modulated by Compression in an Animal Model of Hypertrophic Scar.
- Alkhalil A, Carney BC, Travis TE, Muhie S, Miller SA, Ramella-Roman JC, Ghassemi P, Hammamieh R, Jett M, Moffatt LT, Shupp JW.
- Wounds. 2018 Dec;30(12):353-362.
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Rationale for inclusion: Compression has been known to impact scar maturation in burn patients for decades. Understanding of the cellular mechanisms for this modulation has been lacking; this paper identifies broad transcriptome changes in scar after the application of measured compression.
CAVEAT: Animal work
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- The Use of CO2 Fractional Photothermolysis for the Treatment of Burn Scars.
- Levi B, Ibrahim A, Mathews K, Wojcik B, Gomez J, Fagan S, et al
- J Burn Care Res. Mar-Apr 2016;37(2):106-14.
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Rationale for inclusion: Retrospective study performed at one institution that focuses on patient reported outcomes.
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- Laser resurfacing and remodeling of hypertrophic burn scars: the results of a large, prospective, before-after cohort study, with long-term follow-up.
- Hultman CS, Friedstat JS, Edkins RE, Cairns BA, Meyer AA.
- Ann Surg. 2014 Sep;260(3):519-29; discussion 529-32.
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Rationale for inclusion: For the first time, ever, in a large prospective study, laser therapies have been shown to dramatically improve both the signs and symptoms of hypertrophic burn scars, as measured by objective and subjective instruments. Follow up.
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- Laser therapy for prevention and treatment of pathologic excessive scars.
- Jin R, Huang X, Li H, Yuan Y, Li B, Cheng C, et al
- Plast Reconstr Surg . 2013 Dec;132(6):1747-1758.
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Rationale for inclusion: This study presents the first meta-analysis to confirm the efficacy and safety of laser therapy in hypertrophic scar management.
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- Prospective, before-after cohort study to assess the efficacy of laser therapy on hypertrophic burn scars.
- Hultman CS, Edkins RE, Wu C, Calvert CT, Cairns BA.
- Ann Plast Surg. 2013 May;70(5):521-6.
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Rationale for inclusion: One of the first studies on application of laser therapy to hypertrophic burns scars, identifying indications and efficacy.
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- Pruritus in adult burn survivors: postburn prevalence and risk factors associated with increased intensity
- Carrougher GJ, Martinez EM, McMullen KS, Fauerbach JA, Holavanahalli RK, Herndon DN, Wiechman SA, Engrav LH, Gibran NS
- Carrougher GJ, Martinez EM, McMullen KS, et al. Pruritus in adult burn survivors: postburn prevalence and risk factors associated with increased intensity. J Burn Care Res 2013;34:94–101.
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Rationale for Inclusion: Represents the largest longitudinal report of pruritus symptoms post burn injury. Early after injury 90% of patients reported pruritus, and in long term survivors 44% had pruritus symptoms t 40-10 years.
CAVEAT: Based on patient reported symptoms
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- Shine on: Review of Laser- and Light-Based Therapies for the Treatment of Burn Scars.
- Hultman CS, Edkins RE, Lee CN, Calvert CT, Cairns BA.
- Dermatol Res Pract. 2012;2012:243651.
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Rationale for inclusion: A review of treatment of burn scars with laser therapy to suggest a new direction in laser reconstruction algorithm. (1) vascular-specific pulsed dye laser (PDL) to reduce hyperemia, (2) ablative fractional CO(2) laser to improve texture and pliability of the burn scar, and (3) intense pulsed light (IPL) to correct burn scar dyschromia and alleviate chronic folliculitis.
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- Gabapentin for the treatment of itching produced by burns and wound healing in children: a pilot study.
- Mendham JE.
- Burns. 2004 Dec;30(8):851-3.
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Rationale for inclusion: Literature describing use of gabapentin in the treatment of children with post-burn injury itch. 35 kids who were on other medications with persistent itch were treated with gabapentin and all had improvements in itching with the medication.
CAVEAT: Single center, pediatric only, not randomized or otherwise controlled
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