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- Single Bolus Injection of Bilirubin Improves the Clinical Outcome in A Mouse Model of Endotoxemia
- Published on Nov 1, 2007 from Shock
- Increasing serum levels of biliverdin and bilirubin was shown to be beneficial in settings of inflammation. Bilirubin was shown to be protective in LPS-induced lung injury in rats; however, the exact mechanism remains elusive. Here, we investigated w…
- Stem Cell Mechanisms and Paracrine Effects: Potential in Cardiac Surgery
- Published on Oct 1, 2007 from Shock
- Heart disease remains the leading cause of death in the industrialized world. Stem cell therapy is a promising treatment modality for injured cardiac tissue. A novel mechanism for this cardioprotection may include paracrine actions. Cardiac surgery r…
- The Ratio of Blood Products Transfused Affects Mortality in Patients Receiving Massive Transfusions at a Combat Support Hospital
- Published on Oct 1, 2007 from J Trauma
- Background: Patients with severe traumatic injuries often present with coagulopathy and require massive transfusion. The risk of death from hemorrhagic shock increases in this population. To treat the coagulopathy of trauma, some have suggested early…
- Antisepsis, Disinfection, and Sterilization: Types, Action, and Resistance
- Published on Sep 1, 2007 from Shock
- No abstract available
- Effects of Cd14-159 C/T Polymorphism on Cd14 Expression and the Balance Between Proinflammatory and Anti-Inflammatory Cytokines in Whole Blood Culture
- Published on Aug 1, 2007 from Shock
- CD14 is an important receptor of innate immunity. When CD14 is anchored by ligands to LPS, peptidoglycans, or lipoteichoic acid, it can result in either proinflammatory or anti-inflammatory responses. To determine whether CD14-159 C/T polymorphism is…
- Research and Applications in Bacteriocins
- Published on Aug 1, 2007 from Shock
- No abstract available
- Colon Ascendens Stent Peritonitis-A Model of Sepsis Adopted To the Rat: Physiological, Microcirculatory and Laboratory Changes
- Published on Jul 1, 2007 from Shock
- The colon ascendens stent peritonitis (CASP) procedure creates an intestinal leakage of feces, resulting in diffuse peritonitis and polymicrobial sepsis. Mouse models of CASP have been used to study sepsis experimentally. The aim of the present study…
- Fluid Resuscitation in Severe Sepsis and Septic Shock: Albumin, Hydroxyethyl Starch, Gelatin or Ringer's Lactate-Does It Really Make A Difference?
- Published on May 1, 2007 from Shock
- The aim of this study was to investigate whether the type of i.v. fluid administered has an impact on outcome in an animal model of septic shock. The study included 28 anesthetized, invasively monitored, mechanically ventilated female sheep (29.5 +/-…
- Dynamic Near-Infrared Spectroscopy Measurements in Patients With Severe Sepsis
- Published on Apr 1, 2007 from Shock
- This study evaluated near-infrared spectroscopy (NIRS)-derived measurements in hemodynamically stable patients with severe sepsis, as compared with similar measurements in healthy age-matched volunteers. Prospective, preliminary, observational study …
- High Passage Number of Stem Cells Adversely Affects Stem Cell Activation and Myocardial Protection
- Published on Dec 1, 2006 from Shock
- Progenitor cell plasticity enhances positive remodeling of damaged tissue. We and others have previously shown that progenitor cells may limit apoptosis and modulate inflammation in part by the production of growth factors. However, recent studies su…
- Mof, Mods, and Sirs: What Is in A Name or An Acronym?
- Published on Nov 1, 2006 from Shock
- The most prominent contributions to multiple organ failure, multiple organ dysfunction syndrome, and systemic inflammatory response syndrome are described in this article. However, it is quite possible that there are others that have been missed. The…
- Endothelium-Derived Microparticles Induce Endothelial Dysfunction and Acute Lung Injury
- Published on Nov 1, 2006 from Shock
- Acute lung injury (ALI) carries a high mortality in critically ill patients. Recent reports correlate elevated concentrations of endothelium-derived microparticles (EMPs) with diseases of endothelial dysfunction. Many of these diseases have ALI seque…
- Emerging Paradigm: Toll-Like Receptor 4-Sentinel for the Detection of Tissue Damage
- Published on Nov 1, 2006 from Shock
- The systemic inflammatory response syndrome initiated by infection shares many features in common with the trauma-induced systemic response. The toll-like receptors (TLRs) stand at the interface of innate immune activation in the settings of both inf…
- Vasoactive Drug Support in Septic Shock
- Published on Nov 1, 2006 from Shock
- No abstract available
- Principles and Practice of Mechanical Ventilation, 2Nd Edition
- Published on Oct 1, 2006 from Shock
- No abstract available
- Biomarkers of Acute Renal Injury and Renal Failure
- Published on Sep 1, 2006 from Shock
- Acute renal failure (ARF) is a frequent problem in the intensive care unit and is associated with a high mortality. Early recognition could help clinical management, but current indices lack sufficient predictive value for ARF. Therefore, there might…
- Hmgb1 Signals Through Toll-Like Receptor (Tlr) 4 and Tlr2
- Published on Aug 1, 2006 from Shock
- In response to bacterial endotoxin (e.g., LPS) or endogenous proinflammatory cytokines (e.g., TNF and IL-1[beta]), innate immune cells release HMGB1, a late cytokine mediator of lethal endotoxemia and sepsis. The delayed kinetics of HMGB1 release mak…
- The Cellular, Metabolic, and Systemic Consequences of Aggressive Fluid Resuscitation Strategies
- Published on Aug 1, 2006 from Shock
- Increasing evidence has demonstrated that aggressive crystalloid-based resuscitation strategies are associated with cardiac and pulmonary complications, gastrointestinal dysmotility, coagulation disturbances, and immunological and inflammatory mediat…
- Effects of Dexamethasone on Macrophage Migration Inhibitory Factor Production in Sepsis
- Published on Aug 1, 2006 from Shock
- Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that plays a major role in the pathogenesis of sepsis. Some studies have indicated that glucocorticoids increase MIF production in physiological conditions. The goal of this s…