Completed Studies
Includes studies that have reached completion and have provided EAST information regarding abstract presentation and manuscript acceptance and have corresponded that the study is complete. All information (e.g. study proposals) are available upon request.Completed 2021 Studies
Scanning the Aged to Minimize Missed Injury, an EAST Multicenter Trial
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Principal Investigators & Contact Information: |
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Vanessa P. Ho, MD, MPH |
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MetroHealth Medical Center |
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Sami K. Kishawi, MD (Co-primary investigator) |
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Laura R. Brown, MD, PhD (Co-primary investigator) |
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Jeffrey A. Claridge, MD, MS (Co-primary investigator) |
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Ho, Vanessa P. MD, PhD, MPH1,3; Kishawi, Sami K. MD1,2; Hill, Hannah MS4; O’Brien, Joseph BA1; Ratnasekera, Asanthi DO5; Seng, Sirivan Suon MD5; Ton, Trieu Hai DO5; Butts, Christopher A. PhD, DO6; Muller, Alison MSPH6; Diaz, Bernardo Fabian Jr MD6; Baltazar, Gerard A. DO7; Petrone, Patrizio MD, PhD, MPH, MHSA7; Pacheco, Tulio Brasileiro Silva MD7; Morrissey, Shawna DO8; Chung, Timothy DO8; Biller, Jessica DO8; Jacobson, Lewis E. MD9; Williams, Jamie M. MSML, BSN, RN, CCRP9; Nebughr, Cole S.9; Udekwu, Pascal O. MBBS, MBA/MHA10; Tann, Kimberly BS10; Piehl, Charles BA10; Veatch, Jessica M. MD, MS11; Capasso, Thomas J. MD, MA11; Kuncir, Eric J. MD, MS11; Kodadek, Lisa M. MD12; Miller, Samuel M. MD, MHS12; Altan, Defne AB12; Mentzer, Caleb DO13; Damiano, Nicholas BS, MA13; Burke, Rachel BS13; Earley, Angela MD14; Doris, Stephanie DO14; Villa, Erica DO14; Wilkinson, Michael C. MD15; Dixon, Jacob K. MD15; Wu, Esther MD15; Moncrief, Melissa L. MD16; Palmer, Brandi MS, LPC16; Herzing, Karen MSN, RN16; Egodage, Tanya MD17; Williams, Jennifer MD17; Haan, James MD18; Lightwine, Kelly BS, MPH18; Colling, Kristin P. MD19; Harry, Melissa L. PhD, MSW19,20; Nahmias, Jeffry MD, MHPE21; Tay-Lasso, Erika MD21; Cuschieri, Joseph MD22; Hinojosa, Christopher J. AB22; Claridge, Jeffrey A. MD, MS1. Scanning the aged to minimize missed injury: An EAST multicenter study. Journal of Trauma and Acute Care Surgery ():10.1097/TA.0000000000004390, May 27, 2024. | DOI: 10.1097/TA.0000000000004390 |
Wound Management in Emergency Colorectal Surgery: To Close or Not to Close?
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Principal Investigators & Contact Information: |
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Cristina Barbosa Feather, MD, MHS, FACS |
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Anne Arundel Medical Center |
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J. Robert Klune, MD, MBA, FACS (Co-primary investigator) |
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Justin Turcotte, Ph.D., MBA (Co-primary investigator) |
Development and Validation of a Prehospital Triage Model for the Severely Injured Trauma Patient
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Principal Investigator & Contact Information: |
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Rachel S. Morris, MD |
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Medical College of Wisconsin |
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Christopher J Tignanelli, MD (Co-primary investigator) |
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Biesboer EA, Pokrzywa CJ, Karam BS, Chen B, Szabo A, Teng BQ, Bernard MD, Bernard A, Chowdhury S, Hayudini AE, Radomski MA, Doris S, Yorkgitis BK, Mull J, Weston BW, Hemmila MR, Tignanelli CJ, de Moya MA, Morris RS. Prospective validation of a hospital triage predictive model to decrease undertriage: an EAST multicenter study. Trauma Surg Acute Care Open. 2024 May 2;9(1):e001280. doi: 10.1136/tsaco-2023-001280. PMID: 38737811; PMCID: PMC11086287. |
Intravascular access in hypotensive trauma patients: an Eastern Association for the Surgery of Trauma multicenter prospective observational trial using trauma video review
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Principal Investigators & Contact Information: |
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Ryan P. Dumas MD, FACS |
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UTSW Medical Center / Parkland Memorial Hospital |
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Michael A. Vella, MD (Co-primary investigator) |
Outcomes of Early Initiation of Venous Thromboembolism Prophylaxis in Isolated Traumatic Brain Injuries
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Principal Investigators & Contact Information: |
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Asanthi Ratnasekera DO FACS & Daniel Kim MD |
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Crozer |
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Ammar Humayun MD (Co-primary investigator) |
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Sirivan Seng MD (Co-primary investigator) |
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Alexander Papa BS (Co-primary investigator) |
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Danielle Lapoint BS (Co-primary investigator) |
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Sandra Durgin MSN, TCRN (Co-primary investigator) |
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Paula Ferrada MD FACS (Mentor) |
Completed 2020 Studies
*Prospective, multi-center, randomized, parallel-control, superiority, pragmatic study comparing administration of clotting factors concentrates with a standard massive hemorrhage protocol in severely bleeding trauma patients
*enrollment open to only centers located in Canada
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Principal Investigator & Contact Information: |
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Luis T da Luz , MD, MSc |
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Sunnybrook Health Sciences Centre - University of Toronto |
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luis.daluz@sunnybrook.ca |
Cognitive Outcomes and NeuroStimulants among the Cerebrally Injured & Obtunded in the United States: The CONSCIOUS Study
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Principal Investigator & Contact Information: |
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Brett M. Tracy, MD |
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The Ohio State University Wexner Medical Center |
Rates of Surgical Superficial Site Infections with Closure of Damage Control Laparotomy Incisions with Wicks/Incisional Wound Vacs
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Principal Investigators & Contact Information: |
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Katherine Pellizzeri, MD |
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PRISMA Health System |
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John Cull, MD, FACS |
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PRISMA Health System |
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Cull J, Pellizzeri K, Cullinane DC, Cochran-Yu M, Trevizo E, Goldenberg-Sandau A, Field R, Kirsch JM, Staszak JK, Skubic JJ, Barreda R, Brigode WM, Bokhari F, Guidry CA, Basham J. Wound infection rate after skin closure of damage control laparotomy with wicks or incisional negative wound therapy: An EAST multi-center trial. Injury. 2024 Nov;55(11):111906. doi: 10.1016/j.injury.2024.111906. Epub 2024 Sep 19. PMID: 39317143. |
Prospective comparison of a short versus long chest tube water seal trial for traumatic pneumothorax
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Principal Investigator & Contact Information: |
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Stephen Varga, MD |
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Inova Fairfax Hospital |
Defining Outcomes after Ultra-Massive Transfusion in the Modern Era of Balanced and Goal-Directed Resuscitation
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Principal Investigators & Contact Information: |
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Zachary A. Matthay, MD |
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UCSF - San Francisco General Hospital |
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Lucy Z. Kornblith, MD |
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UCSF - San Francisco General Hospital |
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Rachael A. Callcut, MD, MSPH, FACS |
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UCSF - San Francisco General Hospital |
Management of Acute Appendicitis and Cholecystitis During the COVID-19 Pandemic: An EAST Multicenter Contemporaneous Cohort Study
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Principal Investigator & Contact Information: |
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Rondi B. Gelbard, MD |
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University of Alabama at Birmingham |
EAST Multicenter Trial: Damage Control Thoracotomy (DCT) in Thoracic Trauma
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Principal Investigator & Contact Information: |
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Ashley Meagher, MD MPH |
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Indiana University School of Medicine |
Prehospital end-tidal carbon dioxide is predictive of death and massive transfusion in injured patients: An Eastern Association for Surgery of Trauma multicenter trial
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Principal Investigator & Contact Information: |
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Eric M. Campion MD |
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Denver Health Medical Center /University of Colorado, Anschutz |
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J Trauma Acute Care Surg. 2022 Feb 1;92(2):355-361. doi: 10.1097/TA.0000000000003447. |
Use of Andexanet Alfa versus KCentra for Reversal of Direct Oral Factor Xa Inhibitors: An EAST Multicenter Study Proposal
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Principal Investigators & Contact Information: |
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Jordan M. Estroff, MD, FACS |
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George Washington University |
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Babak Sarani, MD, FACS, FCCM |
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George Washington University |
Medical Management of Grade 1 and 2 Splenic Injuries with active extravasation
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Principal Investigators & Contact Information: |
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Kristen Spoor, MD |
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Prisma Health’s Greenville Memorial Hospital |
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John Cull, MD, FACS |
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Greenville Health System |
Completed 2019 Studies
Prospective Multicenter Derivation and Validation of a NECROtizing Soft tissue Infection Score (NECROSIS)
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Principal Investigator & Contact Information: |
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Dennis Y. Kim, MD |
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Harbor-UCLA Medical Center |
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Kim, Dennis Y. MD, MMEd, FACS, FRCSC1; Iavasile, Amanda2; Kaji, Amy H. MD, PhD3; Nahmias, Jeffry MD, MHPE4; Grigorian, Areg MD5; Mukherjee, Kaushik MD, MSCI6; Penaloza, Liz MD6; Posluszny, Joseph MD7; Logan, Charles D. MD8; Michelin, Erika MD9; Serena, Thomas DO9; Sahr, Sheryl MD, MS10; Bekdache, Khaldoun MD11; Stoddard, Nathan12; Choudhry, Asad MD13; Zerna Encalada, Ronald MD13; Saltzman, Darin MD, PhD14; Padilla, Reynaldo BA14; Truitt, Michael MD15; Grossman Verner, Heather MS16; Hunt, Darren MD17; Purvis, Victoria MD17; Ross, Samuel Wade MD, MPH18; Mallah, Mike M. MD18; Dultz, Linda MD, MPH19; Kuhlenschmidt, Kali MD19; Mentzer, Caleb J. DO20; Lonkar, Adwait DO20; Chang, Grace MD21; Lemon, Brittney DO21; de Virgilio, Christian MD22. Prospective derivation and validation of a NECROtizing Soft tissue InfectionS (NECROSIS) score: An EAST multicenter trial. Journal of Trauma and Acute Care Surgery ():10.1097/TA.0000000000004374, May 9, 2024. | DOI: 10.1097/TA.0000000000004374 |
Anticoagulation in Emergency General Surgery: Who bleeds more? The ACES TRIAL
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Principal Investigator & Contact Information: |
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Lindsay O'Meara, CRNP |
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University of Maryland Medical Center |
Brain vs. Bone: Does fracture fixation technique influence outcomes in patients with traumatic brain injury (TBI)?
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Principal Investigator & Contact Information: |
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Mira Ghneim, MD |
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R Adams Cowley Shock Trauma Center |
A Comprehensive and Collaborative Review of the Use of Whole Blood at Trauma Centers in the United States
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Principal Investigators & Contact Information: |
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Joshua P. Hazelton, DO, FACS, FACOS |
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Penn State Hershey Medical Center |
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Anna Ssentongo, MPH |
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Penn State Hershey Medical Center |
Outcomes after acute care surgery and trauma care in incarcerated individuals: a prospective observational trial
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Principal Investigator & Contact Information: |
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Rebecca Maine, MD |
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University of Washington |
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J Trauma Acute Care Surg. 2022 Jul 1;93(1):75-83. doi: 10.1097/TA.0000000000003614. Epub 2022 Apr 1. |
Sedation and paralytic use in open abdomen patients-results from the EAST SLEEP Survey
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Principal Investigator & Contact Information: |
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Kaushik Mukherjee MD MSCI FACS |
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Loma Linda University Medical Center |
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Surgery. 2019 Dec;166(6):1111-1116. doi: 10.1016/j.surg.2019.07.017. Epub 2019 Sep 6. |
An Eastern Association for the Surgery of Trauma multicenter trial examining prehospital procedures in penetrating trauma patients
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Principal Investigator & Contact Information: |
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Sharven Taghavi, MD |
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Tulane University School of Medicine |
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J Trauma Acute Care Surg. 2021 Jul 1;91(1):130-140. doi: 10.1097/TA.0000000000003151. |
Completed 2018 Studies
Prospective, Observational Trial of Blunt Cerebrovascular Injury Management and Stroke Formation
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Principal Investigators & Contact Information: |
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Margaret H Lauerman, MD |
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University of Maryland |
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Deborah M. Stein, MD, MPH, FACS, FCCM |
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UCSF |
The Time Has Come To Question the ABCs Priorities of Trauma: Circulation First a Multicenter Prospective observational trial
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Principal Investigator & Contact Information: |
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Paula Ferrada, MC, FACS |
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Virginia Commonwealth University |
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Ferrada, P., García, A., Duchesne, J. et al. Comparing outcomes in patients with exsanguinating injuries: an Eastern Association for the Surgery of Trauma (EAST), multicenter, international trial evaluating prioritization of circulation over intubation (CAB over ABC). World J Emerg Surg 19, 15 (2024). https://doi.org/10.1186/s13017-024-00545-8 |
Characteristics of survivors of civilian public mass shootings: An Eastern Association for the Surgery of Trauma multicenter study
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Principal Investigator & Contact Information: |
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Babak Sarani, MD |
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George Washington University |
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Journal of Trauma and Acute Care Surgery: April 2021 - Volume 90 - Issue 4 - p 652-658 |
Multicenter Prospective Observational Study of Trauma Patients on Antiplatelet Agents
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Principal Investigator & Contact Information: |
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Brian K. Yorkgitis, DO, FACS |
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University of Florida- Jacksonville |
Outcomes in patients with gunshot wounds to the brain
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Principal Investigator & Contact Information: |
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Robert D. Winfield, M.D., FACS |
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University of Kansas Medical Center |
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Trauma Surg Acute Care Open. 2019 Nov 17;4(1):e000351. doi: 10.1136/tsaco-2019-000351. eCollection 2019. |
Contemporary management of traumatic cervical and thoracic esophageal perforation: The results of an Eastern Association for the Surgery of Trauma multi-institutional study
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Principal Investigators & Contact Information: |
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Lauren Raff, MD |
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UNC School of Medicine |
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Patrick L Bosarge, MD |
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University of Arizona College of Medicine - Phoenix |
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J Trauma Acute Care Surg. 2020 Oct;89(4):691-697. doi: 10.1097/TA.0000000000002841. |
Colorectal resection in emergency general surgery: An EAST multicenter trial
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Principal Investigators & Contact Information: |
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Brittany O. Aicher, MD |
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University of Maryland Medical Center |
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Brandon R. Bruns, MD |
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Capital Region Health, University of Maryland |
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J Trauma Acute Care Surg. 2020 Dec;89(6):1023-1031. doi: 10.1097/TA.0000000000002894. |
Timing and volume of crystalloid and blood products in pediatric trauma: An Eastern Association for the Surgery of Trauma multicenter prospective observational study
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Principal Investigators & Contact Information: |
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Richard A. Falcone, Jr, MD, MPH |
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Cincinnati Children's Hospital |
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Stephanie Polites MD, MPH & Juan Gurria MD |
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Mayo Clinic |
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Journal of Trauma and Acute Care Surgery: July 2020 - Volume 89 - Issue 1 - p 36-42 doi: 10.1097/TA.0000000000002702 |
Prospective validation of the Emergency Surgery Score in emergency general surgery: An Eastern Association for the Surgery of Trauma multicenter study
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Principal Investigator & Contact Information: |
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Haytham Kaafarani, MD, MPH, FACS |
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Massachusetts General Hospital |
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Journal of Trauma and Acute Care Surgery: July 2020 - Volume 89 - Issue 1 - p 118-124 doi: 10.1097/TA.0000000000002658 |
The incidence of venous thromboembolic events in trauma patients after tranexamic acid administration: an EAST multicenter study
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Principal Investigators & Contact Information: |
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Babak Sarani, MD |
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George Washington University |
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Lisbi Rivas, MD |
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Blood Coagul Fibrinolysis. 2021 Jan 1;32(1):37-43. doi: 10.1097/MBC.0000000000000983. |
Completed 2017 Studies
Can we be FASTeR? A multicenter study utilizing Right sided roll to improve sensitivity of the FAST
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Principal Investigators & Contact Information: |
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Dr. Seong Lee |
Multicenter prospective observational trial of temporary intravascular shunts for trauma
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Principal Investigators & Contact Information: |
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Mark J. Seamon, MD |
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Hospital of the University of Pennsylvania |
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Lily Tung, MD |
Current Management of Suspected Retained Common Bile Duct Stones in Gallstone Pancreatitis and Choledocholithiasis
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Principal Investigator & Contact Information: |
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Rondi Gelbard, MD |
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Emory University School of Medicine |
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2020 Jul;168(1):62-66. doi: 10.1016/j.surg.2020.04.011. Epub 2020 May 26. |
Multicenter Study of the Treatment of Appendicitis in America Acute, Perforated, and Gangrenous (MUSTANG), an EAST Multicenter Study
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Principal Investigator & Contact Information: |
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Daniel Dante Yeh, MD |
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Ryder Trauma Center |
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Annals of Surgery: October 28, 2019 - Volume Publish Ahead of Print - Issue - p doi: 10.1097/SLA.0000000000003661 |
Use of regional analgesia and risk of delirium in older adults with multiple rib fractures: An Eastern Association for the Surgery of Trauma multicenter study
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Principal Investigators & Contact Information: |
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Saman Arbabi M.D., M.P.H., F.A.C.S. |
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Harborview Medical Center |
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Kathleen O'Connell MD |
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University of Washington |
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J Trauma Acute Care Surg. 2021 Aug 1;91(2):265-271. doi: 10.1097/TA.0000000000003258. |
EAST multicenter trial of simulation-based team training for pediatric trauma: Resuscitation task completion is highly variable during simulated traumatic brain injury resuscitation
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Principal Investigators & Contact Information: |
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Aaron R. Jensen, MD, Med |
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Children's Hospital Los Angeles |
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Jensen et al. EAST multicenter trial of simulation based training for pediatric trauma: resuscitation task completion is highly variable during simulated traumatic brain injury resuscitation. Am J Surg 2020. 219(6):1057-64. PMID 31421895. |
Infection after penetrating brain injury—An Eastern Association for the Surgery of Trauma multicenter study
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Principal Investigators & Contact Information: |
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Deborah Stein, MD, MPH |
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R Adams Cowley Shock Trauma Ctr |
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Laura Harmon, MD |
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R Adams Cowley Shock Trauma Ctr |
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Journal of Trauma and Acute Care Surgery: July 2019 - Volume 87 - Issue 1 - p 61-67 doi: 10.1097/TA.0000000000002327 |
Completed 2016 Studies
Reducing Routine Phlebotomy in Stable Liver and Splenic Injuries
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Principal Investigator & Contact Information: |
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Jose Prince, MD |
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J Pediatr Surg. 2019 Nov;54(11):2363-2368. doi: 10.1016/j.jpedsurg.2019.04.021. Epub 2019 May 6. |
Anticoagulation therapy in patients with traumatic brain injury: An Eastern Association for the Surgery of Trauma multicenter prospective study
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Principal Investigator & Contact Information: |
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Kazuhide Matsushima, MD |
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LAC+USC Medical Center, University of Southern California |
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Surgery. 2020 Sep 12;S0039-6060(20)30512-2. doi: 10.1016/j.surg.2020.07.040. Online ahead of print. |
Blunt small bowel perforation (SBP): An Eastern Association for the Surgery of Trauma multicenter update 15 years later
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Principal Investigators & Contact Information: |
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Samir M Fakhry M.D. (Senior Investigator) |
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Ahmed Allawi, MD (Co-Investigator) |
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Medical University of South Carolina |
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Journal of Trauma and Acute Care Surgery: April 2019 - Volume 86 - Issue 4 - p 642-650 doi: 10.1097/TA.0000000000002176 |
EAST multicenter trial on targeted temperature management for hanging-induced cardiac arrest
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Principal Investigators & Contact Information: |
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Deborah Stein, MD (Senior Investigator) & Cindy Hsu, MD, PhD |
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R Adams Cowley Shock Trauma Ctr |
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Journal of Trauma and Acute Care Surgery: July 2018 - Volume 85 - Issue 1 - p 37-47 doi: 10.1097/TA.0000000000001945 |
Completed 2015 Studies
Prospective Multi-Institutional Evaluation of the Management of Cholecystostomy
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Principal Investigators & Contact Information: |
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Nathaniel Poulin, MD |
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The Brody School of Medicine at ECU |
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Eric A. Toschlog, MD, FACS, FCCM |
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East Carolina University |
Multi-institutional, prospective, observational study comparing the Gastrografin challenge versus standard treatment in adhesive small bowel obstruction
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Principal Investigator & Contact Information: |
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Martin D. Zielinski, MD, FACS |
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Mayo Clinic |
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Journal of Trauma and Acute Care Surgery: July 2017 - Volume 83 - Issue 1 - p 47-54 doi: 10.1097/TA.0000000000001499 |
Predictors of Retained Hemothorax in Trauma Results of an EAST Multi-Institutional Trial
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Principal Investigator & Contact Information: |
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Jeremy W. Cannon, MD, SM, FACS |
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Perelman School of Medicine at the University of Pennsylvania |
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Priya S. Prakash, MD (assisting) |
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Journal of Trauma and Acute Care Surgery: July 8, 2020 - Volume Publish Ahead of Print - Issue - doi: 10.1097/TA.0000000000002881 |
Screening for Harassment, Abuse, and Discrimination among Surgery Residents: An EAST Multicenter Trial
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Principal Investigator & Contact Information: |
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Rondi Gelbard, MD |
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Emory University School of Medicine |
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Fitzgerald CA, Smith RN, Luo-Owen X, et al. Screening for Harassment, Abuse, and Discrimination among Surgery Residents: An EAST Multicenter Trial. Am Surg. 2019;85(5):456-461. |
Can acute care surgeons perform while fatigued? An EAST multicenter study
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Principal Investigator & Contact Information: |
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Kevin M. Schuster, MD |
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Yale School of Medicine |
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Journal of Trauma and Acute Care Surgery: September 2018 - Volume 85 - Issue 3 - p 476-484 doi: 10.1097/TA.0000000000001975 |
Platelet Transfusion Does Not Improve Outcomes in Brain Injured Patients on Antiplatelet Therapy
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Principal Investigator & Contact Information: |
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Babak Sarani, MD, FACS, FCCM |
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George Washington University |
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(2018) Platelet transfusion does not improve outcomes in patients with brain injury on antiplatelet therapy, Brain Injury, 32:3, 325-330, DOI: 10.1080/02699052.2018.1425804 |
Universal screening for intimate partner and sexual violence in trauma patients
An EAST multicenter trial
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Principal Investigator & Contact Information: |
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Tanya L. Zakrison, MD, MPH, FRCSC, FACS |
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Miller School of Medicine |
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Journal of Trauma and Acute Care Surgery: July 2017 - Volume 83 - Issue 1 - p 105-110 doi: 10.1097/TA.0000000000001495 |
Loop ileostomy versus total colectomy as surgical treatment for Clostridium difficile–associated disease An Eastern Association for the Surgery of Trauma multicenter trial
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Principal Investigators & Contact Information: |
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Paula Ferrada, MD |
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Virginia Commonwealth University |
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Rachael Callcut, MD, MSPH, FACS |
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UCSF |
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Journal of Trauma and Acute Care Surgery: July 2017 - Volume 83 - Issue 1 - p 36-40 doi: 10.1097/TA.0000000000001498 |
Incompatible type A plasma transfusion in patients requiring massive transfusion protocol
Outcomes of an Eastern Association for the Surgery of Trauma multicenter study
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Principal Investigator & Contact Information: |
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Andrew C. Bernard, MD |
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Univ of Kentucky College of Medicine |
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Journal of Trauma and Acute Care Surgery: July 2017 - Volume 83 - Issue 1 - p 25-29 doi: 10.1097/TA.0000000000001532 |